業績Publications

論文

1. Hirai M, Ikeda A, Kato T, Ikeda T, Asada K, Hakuno Y, Matsushima K, Awaya T, Okazaki S, Kato T, Heike T, Hagiwara M, Yamagata T, Tomiwa K, Kimura R.
   Comparison of the sensory profile among autistic individuals and individuals with Williams syndrome.
   Journal of Autism and Developmental Disorders. 2024 https://doi.org/10.1007/s10803-023-06205-1
2. Lo T, Kushima I, Kimura H, Aleksic B, Okada T, Kato H, Inada T, Nawa Y, Torii Y, Yamamoto M, Kimura R, Funabiki Y, Kosaka H, Numata S, Kasai K, Sasaki T, Yokoyama S, Munesue T, Hashimoto R, Yasuda Y, Fujimoto M, Usami M, Itokawa M, Arai M, Ohi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Yamasue H, Iwata N, Ikeda M, Ozaki N.
   Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study.
   Neuropsychopharmacology Reports. 44(1): 42-50, 2024
3. Hirai M, Asada K, Kato T, Ikeda T, Hakuno Y, Ikeda A, Matsushima K, Awaya T, Okazaki S, Kato T, Funabiki Y, Murai T, Heike T, Hagiwara M, Yamagata T, Tomiwa K, Kimura R.
   Comparison of the social responsiveness scale-2 among individuals with autism spectrum disorder and Williams syndrome in Japan.
   Journal of Autism and Developmental Disorders. 54(8): 3176-3184, 2024
4. Okazaki S, Kimura R, Otsuka I, Tomiwa K, Funabiki Y, Hagiwara M, Murai T, Hishimoto A.
   Epigenetic aging in Williams syndrome.
   Journal of Child Psychology and Psychiatry. 63(12): 1553-1562, 2022
5. Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Ogawa N, Iritani S, Hayashi Y, Lo T, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M, Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H, Wakuda T, Kato T, Kanba S, Horikawa H, Usami M, Kodaira M, Watanabe K, Yoshikawa T, Toyota T, Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung M, Kasai K, Ikegame T, Jinde S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto Y, Okumura Y, Ito T, Arioka Y, Mori D, Ozaki N.
   Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder.
   Biological Psychiatry. 92(5) 362-374, 2022
6. Okazaki S, Kimura R, Otsuka I, Funabiki Y, Murai T, Hishimoto A.
   Epigenetic clock analysis and increased plasminogen activator inhibitor-1 in high-functioning autism spectrum disorder.
   PLOS ONE. 17(2) e0263478-e0263478, 2022
7. Kato H, Kushima I, Mori D, Yoshimi A, Aleksic B, Nawa Y, Toyama M, Furuta S, Yu Y, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N.
   Rare Genetic Variants in the Gene Encoding Histone Lysine Demethylase 4C (KDM4C) and Their Contributions to Susceptibility to Schizophrenia and Autism Spectrum Disorder.
   Translational Psychiatry. 10:421, 2020
8. Suzuki S, Kimura R, Maegawa S, Nakata M, Hagiwara M.
   Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.
   Molecular Brain. 13(1):70, 2020
9. Kimura R, Lardenoije R, Tomiwa K, Funabiki Y, Nakata M, Suzuki S, Awaya T, Kato T, Okazaki S, Murai T, Heike T, Rutten BPF, Hagiwara M.
   Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome.
   Neuropsychopharmacology. 45(10):1627-1636, 2020
10. Kimura R, Tomiwa K, Inoue R, Suzuki S, Nakata M, Awaya T, Kato T, Okazaki S, Heike T, Hagiwara M. Dysregulation of the oxytocin receptor gene in Williams syndrome.
    Psychoneuroendocrinology. 115:104631, 2020
11. Nakata M, Kimura R, Funabiki Y, Awaya T, Murai T, Hagiwara M.
    MicroRNA profiling in adults with high-functioning autism spectrum disorder.
    Molecular Brain. 12(1):82, 2019
12. Kimura R, Nakata M, Funabiki Y, Suzuki S, Awaya T, Murai T, Hagiwara M.
    An epigenetic biomarker for adult high-functioning autism spectrum disorder.
    Scientific Reports. 9(1):13662, 2019
13. Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M.
    Integrative network analysis reveals biological pathways associated with Williams syndrome.
    Journal of Child Psychology and Psychiatry. 60(5):585-598, 2019
14. Benítez-Burraco A, Kimura R.
    Robust candidates for language development and evolution are significantly dysregulated in the blood of people with Williams syndrome.
    Frontiers in Neuroscience. 13:258, 2019
15. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights.
    Cell Reports. 24(11):2838-2856, 2018
16. Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M. Williams-Beuren syndrome as a potential risk factor for Burkitt lymphoma.
    Frontiers in Genetics. 9:368, 2018
17. Yoshida, T, Awaya T, Jonouchi T, Kimura R, Kimura S, Era T, Heike T, Sakurai H.
    A skeletal muscle model of infantile-onset Pompe disease with patient-specific iPS cells.
    Scientific Reports. 7(1):13473, 2017
18. Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M.
    Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier.
    Proceedings of the National Academy of Sciences of the United States of America. 111(7): 2638-2643, 2014
19. Kimura R, Ikeda S, Kumazaki H, Yanagida M, Matsunaga H.
    Comparison of the clinical features of suicide attempters by jumping from a height and those by self-stabbing in Japan.
    Journal of Affective Disorders. 150: 695-698, 2013
20. Takaya M, Matsusaka K, Yanagida M, Kimura R, Matsunaga H.
    The effects of memantine on a patient having preclinical dementia with Lewy bodies.
    General Hospital Psychiatry. 35(3): 327.e1-3, 2013
21. Yazaki M, Kinoshita M, Ogawa S, Fujimi S, Matsushima A, Hineno A, Tazawa K, Fukushima K, Kimura R, Yanagida M, Matsunaga H, Saheki T, Ikeda S.
    A 73-year-old patient with adult-onset type Ⅱ citrullinemia successfully treated by sodium pyruvate and arginine.
    Clinical Neurology and Neurosurgery. 115(8): 1542-1545, 2013
22. Kimura R, Mori K, Kumazaki H, Yanagida M, Taguchi S, Matsunaga H.
    Treatment of delirium with ramelteon: initial experience in three patients.
    General Hospital Psychiatry. 33:407-409, 2011
23. Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M, Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines JL, Younkin S, Williams J, van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R; for the Genetic and Environmental Risk in Alzheimer Disease 1 Consortium.
    Meta-analysis of the association between variants in SORL1 and Alzheimer's disease.
    Archives of Neurology. 68:99-106, 2011
24. Kimura R, Morihara T, Kudo T, Kamino K, Takeda M.
    Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population.
    Neuroscience Letters. 487:354-357, 2011
25. Kimura R, Yanagida M, Kugo A, Taguchi S, Matsunaga H.
    Posterior reversible encephalopathy syndrome in chronic alcoholism with acute psychiatric symptoms.
    General Hospital Psychiatry. 32(4): 447.e3-5, 2010
26. Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M. KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.
    Dementia and Geriatric Cognitive Disorders.30:302-308, 2010
27. Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M.
    SORL1 is genetically associated with Alzheimer disease in a Japanese population.
    Neuroscience Letters. 461:177-80, 2009
28. Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik MG, Kamino K, Takeda M.
    Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.
    Biochemical and Biophysical Research Communications. 379:691-5, 2009
29. Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M.
    Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
    Journal of Human Genetics. 53:296-302, 2008
30. Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M.
    A molecular chaperone inducer protects neurons from ER stress.
    Cell Death and Differentiation. 15:364-75, 2008
31. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M.
    The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
    Human Molecular Genetics. 16:15-23, 2007
32. Kanayama D, Kudo T, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, Takeda M.
    Abeta induces endoplasmic reticulum stress causing possible proteasome impairment via the encoplasmic reticulum-associated degradation pathway.
    Psychogeriatrics. 6:100-106, 2006
33. Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M. Altered localization of amyloid precursor protein under endoplasmic reticulum stress.
    Biochemical and Biophysics Research Communications. 344:525-30, 2006
34. Kimura R, Kamino K, Yamamoto M, Kida T, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa BN, Kazui H, Ikejiri Y, Tanaka T, Tanii H, Kudo T, Yoneda H, Yamagata H, Miki T, Takeda M. Albumin gene encoding free fatty acid and beta-amyloid transporter is genetically associated with Alzheimer disease.
    Psychiatry and Clinical Neuroscience. 60: S34-9, 2006
35. Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.
    Psychiatry and Clinical Neuroscience. 60: S27-33, 2006
36. Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
    Journal of Biological Chemistry. 281:7890-8, 2006